P2X3-type ATP receptor-mediated nociception and its specific inhibition by spinorphin
نویسندگان
چکیده
منابع مشابه
Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor.
Synthetic 21-bp-long short interfering RNAs (siRNA) can stimulate sequence-specific mRNA degradation in mammalian cell cultures, a process referred to as RNA interference (RNAi). In the present study, the potential of RNAi was compared to the traditional antisense approach, acting mainly via RnaseH, for targeting the recombinant rat pain-related cation-channel P2X3 expressed in CHO-K1 and a rat...
متن کاملATP P2X3 receptors and neuronal sensitization
Increasing evidence indicates the importance of extracellular adenosine triphosphate (ATP) in the modulation of neuronal function. In particular, fine control of ATP release and the selective and discrete ATP receptor operation are crucial elements of the crosstalk between neuronal and non-neuronal cells in the peripheral and central nervous systems. In peripheral neurons, ATP signaling gives a...
متن کاملInhibition of Guinea-Pig Taenia Coli Mediated by eti-, f}2-Adrenoceptors and ATP-Receptor Activation
The actions of orand /8-adrenoceptor agonists, antagonists and ATP were investigated on the smooth muscle of the guinea-pig taenia coli. Electrical and mechanical activities were recorded by means of the sucrose gap method. Noradrenaline, phenylephrine and methoxamine hyperpolarized the smooth muscle membrane, decreased the membrane resistance, reduced the size of phasic contractions, decreased...
متن کاملAnti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist
BACKGROUND AND PURPOSE The opioid receptor family comprises four structurally homologous but functionally distinct sub-groups, the μ (MOP), δ (DOP), κ (KOP) and nociceptin (NOP) receptors. As most opioid agonists are selective but not specific, a broad spectrum of behaviours due to activation of different opioid receptors is expected. In this study, we examine whether other opioid receptor syst...
متن کاملControl of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons.
Purinergic signaling contributes significantly to pain mechanisms, and the nociceptor-specific P2X3 ATP receptor channel is considered a target in pain therapeutics. Recent findings suggesting the coexpression of metabotropic P2Y receptors with P2X3 implies that ATP release triggers the activation of both ionotropic and metabotropic purinoceptors, with strong potential for functional interactio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48095-5